Effective Immunotherapy in cutaneous warts with MMR vaccine,
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Warts are common viral infection of the skin. Treatment of warts is still an ongoing problem and, despite various clinical methods, no universal consensus is reached on best treatment. Intralesional (IL) immunotherapy has recently been shown to be effective in treating various wart forms. A Study was conducted to assess the efficacy and safety of IL tuberculin, IL MMR vaccine, and intradermal (ID) BCG vaccination in treating viral warts.

60 patients with single or multiple warts were divided equally into three groups.
-Group A received IL MMR vaccine, and
-Group B received IL tuberculin every 3 weeks (maximum 3 times).
-Group C received ID BCG vaccination in the arm with one month interval (maximum 3 times).
Recurrence was followed up for 6 months.

Results:
-In group A, complete response occurred in 30%, partial response in 5%, and no response in 65%.
-In group B, complete response occurred in 45%, partial response in 20%, minimal response in 10% and no response in 25%.
-In group C, complete response occurred in 70%, partial response in 5%, minimal response in 5%, and no response in 20%.
-No recurrence was observed in group A and B but occurred in one patient in group C with the same lesion.

It was concluded that immunotherapy with IL tuberculin and ID BCG vaccines are safe, efficient and inexpensive in the treatment of all forms of warts even if recalcitrant or multiple but IL MMR immunotherapy has been shown to be less effective and less safe.

Source: https://onlinelibrary.wiley.com/doi/full/10.1111/jocd.13921
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