Effectiveness of Combined Intense Pulsed Light and Low-Level
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A Study was conducted to assess the effectiveness of a combination of intense pulsed light and low-level light therapy (IPL/LLLT) for the treatment of dry eye that was found to be safe and effecient.

Patients diagnosed with dry eye, refractory to conventional treatment, underwent four sessions of combined IPL/LLLT over 3 months. The Ocular Surface Disease Index (OSDI) questionnaire, non-invasive breakup time (NIBUT), tear film osmolarity and meniscus height were measured 6 months before intervention, at baseline, post-intervention (3 months), 9 and 15 months.

Results:
--NIBUT, osmolarity and meniscus height significantly worsened during the 6 months before treatment, whereas symptoms did not change.

--OSDI scores significantly improved at post-intervention (MD = - 44.0), and then increased again until the at last follow-up, but still significantly different from baseline (MD = - 30.0).

--The three clinical signs showed a similar pattern, with one-year improvements of 3.6 seconds for the NIBUT, 28 mOsm/L for osmolarity and 0.03 mm for meniscus height. No adverse effects were observed.

In conclusion, IPL/LLLT is healthy and produces a significant reduction in dry eye disease symptoms and signs, which is still true one year after treatment in a study with severe symptoms. As a result, it's a promising therapeutic choice for patients who don't respond to traditional therapy.

Source: https://www.dovepress.com/combined-intense-pulsed-light-and-low-level-light-therapy-for-the-trea-peer-reviewed-fulltext-article-OPTH
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