Effectiveness of zinc chloride mouthwashes on oral mucositis
Oral mucositis is one of the most emerging and debilitating complications of chemotherapy during the treatment period, which strongly affects the nutritional status and physical and mental condition of these patients. Zinc chloride mouthwashes are effective in the prevention of oral mucositis.

Zinc increased protein synthesis and improved cell membrane stability so passible effective in preventing and treating oral mucositis and promote oral health. This study aimed to evaluate the effect of zinc chloride mouthwash on the prevention, incidence, and severity of oral mucositis in cancer patients undergoing chemotherapy.

The present study was a randomized control trial study. 96 patients with a cancer diagnosis were selected. Then they were assigned randomly to the zinc chloride group and placebo group. The patients in each group should rinse their mouths every 8 h two times and each time 2 min with 7.5 ml from mouthwash. The severity of mucositis and weight loss was examined blindly at the baseline and 3-week follow-up.

- The incidence and severity of oral mucositis between groups were significantly higher at the end of the second and third weeks.

- The mucositis severity decreased well during the third week in the zinc chloride group.

- The difference in the weight loss was significantly higher between the zinc chloride and the placebo group.

Conclusively, zinc chloride mouthwash was effective in preventing and reducing the severity of oral mucositis and improving weight in patients undergoing chemotherapy.

BMC Oral Health
Source: https://doi.org/10.1186/s12903-021-01706-w