Effects of Alcohol, Genetic risk & their Potential Interacti
According to The Shanghai Diabetes study (SHDS) carried out recently, there is a strong evidence which suggests that alcohol consumption strongly increases the risk of type 2 diabetes(T2D) by increasing Insulin Resistance, especially in men with low Type 2 Diabetes-Genetic Risk Score(GRS), highlighting the importance of refraining from drinking alcohol when making recommendations for healthy lifestyle habits to prevent diabetes.

Type 2 diabetes, whose development is a progress of blood glucose deterioration, is one of the most common chronic diseases worldwide. Type 2 diabetes originates from both genetic and lifestyle factors, as well as their interactions.

Since alcohol is one of the most widely consumed beverages, investigating whether alcohol intake has an effect on the risk of type 2 diabetes is of great importance to public health.

In the study it was found that, the association of alcohol with type 2 diabetes incidence was strongest in the low T2D-GRS group and weakest in the high GRS group. Specifically, in the low T2D-GRS group, alcohol drinkers had a greater than three times higher risk of glucose deterioration than nondrinker, which corresponded to an increase in the incidence of blood glucose deterioration.

Source: https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-019-0396-x