Effects of Beta-zone Peripapillary Atrophy and Focal Lamina
The development of beta-zone peripapillary atrophy (beta-PPA) and focal lamina cribrosa defect (FLD) was significantly associated with decreased peripapillary optical coherence tomography angiography (OCTA) vessel parameters in young myopic eyes.

The purpose of this study was to investigate whether beta-PPA and FLD affect peripapillary vessel density (VD) or perfusion density (PD) from OCTA in young myopic eyes.

330 eyes of 165 healthy volunteers with myopia were involved. Eyes underwent OCTA to measure peripapillary PD and VD. PD and VD were compared among 3 groups, and linear mixed-effect regression model was used to investigate the determinants of PD.

Results:
--Beta-PPA was found in 219 eyes, and FLD was detected in 27 eyes.

--The average VD and PD were greatest in group A, followed by group B and group C.

--The linear mixed-effect model demonstrated that presence of FLD or beta-PPA, FLD count, and maximal beta-PPA width were significantly associated with average PD after controlling for multiple confounding factors.

Finally, in juvenile myopic eyes, the development of beta-PPA and FLD, which are strongly linked to axial elongation in myopic eyes, was significantly correlated with lower OCTA vascular characteristics. In these eyes, OCTA may aid in the detection of vascular alterations and the assessment of glaucoma risk.

Source: https://journals.lww.com/glaucomajournal/Abstract/2021/08000/Effects_of_Beta_zone_Peripapillary_Atrophy_and.12.aspx
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