Effects of Dexmedetomidine in patients undergoing Laparoscop
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The study states that dexmedetomidine has a positive impact on intraoperative hemodynamics, recovery profile, and postoperative pain in patients undergoing laparoscopic cholecystectomy.

The study was aimed to investigate the optimal dose of dexmedetomidine to maintain hemodynamic stability, prevent cough and minimize postoperative pain for patients undergoing laparoscopic cholecystectomy.

120 patients were randomly divided into D1, D2, D3, and NS groups, and dexmedetomidine 0.4, 0.6, 0.8?g/kg and normal saline were administrated respectively. Patients' heart rate, systolic blood pressure, and diastolic blood pressure were measured at T1-T7. The incidence of cough was recorded. Other parameters were noted, the time of spontaneous respiratory recovery and extubation, visual analog scale scores, and dosage of tramadol.

--The heart rate, systolic blood pressure, and diastolic blood pressure of D2 and D3 groups have smaller fluctuations at T2–3 and T7 compared with NS and D1 groups.

--The incidence of cough was lower in D2 and D3 groups than NS group.

--The visual analog scale scores and tramadol dosage of the D2 and D3 groups were lower than the NS group.

--The time of spontaneous respiratory recovery and extubation in the D3 group was longer than that in D1 and D2 groups.

Conclusively, intravenous infusion of 0.6?g/kg dexmedetomidine before induction can maintain hemodynamic stability, decrease cough during emergence, relieve postoperative pain of patients undergoing laparoscopic cholecystectomy.

BMC Anesthesiology
Source: https://doi.org/10.1186/s12871-021-01283-z
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