Effects of Lid debris debridement Combined with meibomian gl
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This research looked into the effects of lid debris debridement and meibomian gland [removed]MGX) on extracellular matrix metalloproteinase-9 (MMP-9) levels and clinical outcomes of mild and severe MGD.

One session of lid debris debridement using the BlephEx combined with MGX was performed on 48 eyes of 24 patients with moderate and heavy MGD. Researchers used a point-of-care MMP-9 immunoassay system to measure tear film break-up time (TBUT), corneal and conjunctival fluorescein staining scores, Schirmer 1 test, biomicroscopic analysis of lid margins and meibomian gland (MG), ocular surface disease index (OSDI) questionnaire score, and extracellular MMP-9 levels before and four weeks after lid debris debridement and MGX. To assess potential discrepancies, a linear mixed model and a generalized estimating equations model were used.

Results:
--There were significant improvements in the TBUT, SICCA and Oxford staining scores, lid margin telangiectasia, lid thickness, MG orifice plugging, meibum color, meibum consistency for upper and lower eyelids), meibum grade, MGD stage, and OSDI score.

--MMP-9 immunoassay positivity rate significantly decreased from 83.3 to 50.0% 4 weeks after treatment.

Finally, lid debris debridement using the BlephEx in combination with MGX enhanced clinical results, subjective symptoms, meibomian gland activity, and ocular surface MMP-9 levels in patients with moderate to extreme MGD. It is recommend that BlephEx combined with MGX for lid debris debridement as an effective clinical method for treating mild to serious MGD.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01926-2
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