Effects of diabetes on osteocytes
Better understanding of the mechanisms underlying skeletal dysfunction in the context of diabetes is needed to guide the development of therapeutic interventions to reduce the burden of diabetic fractures. Osteocytes, the ‘master regulators’ of bone remodeling, have emerged as key culprits in the pathogenesis of diabetes-related skeletal fragility.

Therefore, interventions targeting the RAGE signaling pathway, senescent cells, and those that inhibit sclerostin or mechanically stimulate osteocytes may alleviate the deleterious effects of diabetes on osteocytes and bone quality.

Source: https://pubmed.ncbi.nlm.nih.gov/35749726/