Effects of endogenous and exogenous oestrogen exposure on he
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To investigate the effect of endogenous and exogenous oestrogen exposure on hearing levels in postmenopausal women a study was conducted. Participants comprised 3,653 postmenopausal women. Detailed histories for reproductive factors and data on the use of hormone replacement therapy were obtained through health questionnaires and otologic examinations, including pure tone audiogram and otoscopic findings. Complex-sample linear regression models controlling for confounding factors were generated to determine whether hormone-related factors were associated with hearing loss.


Women who experienced a longer duration of oestrogen exposure had better hearing compared to those who do not in multivariate model adjusting for confounding factors with a lower adjusted beta coefficient of hearing threshold. The results also suggested that hormone replacement therapy may be beneficial for attenuating hearing loss, particularly in the high-frequency range from 3 kHz to 6 kHz.

A longer duration of lifetime oestrogen exposure (LEE) and the use of hormone replacement therapy is likely to attenuate hearing loss. These epidemiologic data provide evidence that oestrogen may be beneficial for attenuating age-related hearing decline.

Source:https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13685?af=R
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