Efficacy and safety of topical herbal medicineRX on recurren
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Recurrent aphthous stomatitis (RAS), or recurrent aphthous ulcer (RAU), is one of the most common oral diseases, with an estimated prevalence of 25%. Many factors may be involved in its progression, such as genetic predisposition, immunological abnormalities, microbial infection, psychological stress, and hormonal state. Since the etiology and pathogenesis of RAS remains unclear, there is currently no consensus regarding a definitive curative therapy. The commonly accepted treatment strategy is to lessen the pain and duration of lesions.Topical corticosteroids, antibiotics, and analgesics are highly recommended for patients with RAS.However, longer treatment and frequent exposure to these medications may cause fungal infection and drug resistance, which may further lead to more severe adverse effects or even life-threatening complications......

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706126/
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