Efficacy of Dapagliflozin in Adult Autosomal Recessive Alpor
Alport syndrome is a hereditary kidney disease characterized by progressive renal failure, especially for patients with autosomal recessive and X-linked inheritance. This was a real-world study based on our dynamic cohort of Alport syndrome. With a follow-up of 4 to 6 months, proteinuria showed a decreasing trend in all the 3 cases of autosomal recessive Alport syndrome, with 24-hour proteinuria decreasing by 0.17 g/24h (8.9%), 0.61 g/24h (39.9%), and 0.69 g/24h (52.3%) respectively. Urinary albumin-creatinine ratio decreased by 374.92 mg/g (26.9%), 561.03 mg/g (44.0%), and 234.33 mg/g (68.7%), respectively. Correspondingly, the serum albumin showed an increment on the whole. Importantly, the serum creatinine and estimated glomerular filtration rate remained stable. Proteinuria decreased steadily after administration of dapagliflozin.

Source: https://www.kireports.org/article/S2468-0249(22)01474-7/fulltext?rss=yes