Efficacy of Intra-Articular Hypertonic Dextrose for Knee Ost
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Knee osteoarthritis (KOA) is ubiquitous in primary care, leading to pain, disability, and substantial patient and societal costs. Conservative care is limited. While exercise and weight reduction are effective, the degenerative nature of osteoarthritis and the difficulty of behavioral change appears to limit success. A study was conducted to test the efficacy of intra-articular hypertonic dextrose prolotherapy (DPT) vs normal saline (NS) injection for knee osteoarthritis (KOA)

Patients with KOA (n = 76) were randomly allocated for injections at weeks 0, 4, 8, and 16. The primary outcome was the Western Ontario McMaster University Osteoarthritis Index pain score. The secondary outcomes were the WOMAC composite, function and stiffness scores.

The WOMAC pain score at 52 weeks showed a difference-in-difference estimate of −10.34 points. A similar favorable effect was shown on the difference-in-difference estimate on WOMAC function score of −9.55, WOMAC composite score of −9.65, No adverse events were reported.

Conclusively Intra-articular dextrose prolotherapy injections reduced pain, improved function, and quality of life in patients with KOA compared with blinded saline injections. The procedure is straightforward and safe; the adherence and satisfaction were high.

Source:https://www.annfammed.org/content/18/3/235
Like
Comment
Share