Efficacy of budesonide/formoterol maintenance and reliever R
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Abstract

Background :
Asthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dose budesonide plus as-needed terbutaline in patients requiring step-up from Step 2 treatment (low-dose inhaled corticosteroids), stratified by baseline reliever use.

Methods :
A post-hoc analysis utilized data from three clinical trials of 6–12 months’ duration. Patients aged ?12 years with symptomatic asthma uncontrolled despite Step 2 treatment were included. Severe exacerbation rate, lung function and reliever use were analysed, stratified by baseline reliever use (<1, 1–2 and >2 occasions/day)......

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