Elevated mean platelet volume in oral lichen planus and incr
The study shows that mean platelet volume (MPV) has an important role in inflammation in oral lichen planus (OLP). The study was published in the BMC Oral Health.

This retrospective observational study aims to assess platelet count, mean platelet volume (MPV), blood biochemical tests for liver and kidney function in Chinese oral lichen planus (OLP) patients.

Eighty pathologically confirmed OLP patients and 51 healthy controls were enrolled. Data on full blood count and biochemical tests were obtained from the electronic medical record system of the hospital.

- MPV was elevated in OLP patients compared to controls while platelet count showed no difference between them.

- The Red-form OLP group had increased blood urea nitrogen than the white-form OLP group.

- By contrast, there were no differences between those two groups in the other variables including MPV, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and creatinine.

- In terms of CRP, 92.5% of the OLP patients had a value of less than 3.48 mg/L. Besides, 75% of the OLP patients were overweight with a body mass index (BMI) of more than 25 kg/m2.

These findings indicate MPV might play roles in inflammation in OLP. The red-form OLP might be associated with damage or reduction of kidney function.

Source: https://doi.org/10.1186/s12903-021-01659-0