En Face OCT used for identification and Characterization of
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A Study was conducted to describe the clinical features of epivascular glia (EVG) using en face optical coherence tomography (OCT).

En face OCT photographs from a single institution were examined. Manual internal limiting membrane segmentation was used to catch EVG-affected eyes, which were then analyzed using personalized segmentation. To assess relative epiretinal membrane (ERM) prevalence, a random age and gender-matched control group was chosen.

Results:
--Characteristic hyper-reflective internal limiting membrane (ILM) plaques with dendritic-like radiations were identified with en face OCT and displayed vascular predilection.

--161 eyes with EVG (EVG group) and 2315 eyes without EVG (control group) were identified from a total cohort of 1298 patients.

--The prevalence of EVG was 6.5% of eyes and 9.2% of patients in our cohort. Mean age was 79.3±10.7 years in the EVG group and 55.9±24.6 years in the control group.

--Advanced posterior vitreous detachment (PVD) stage was more common in the EVG (grade 3: 41.7%, grade 4: 48.6%) versus the control group (grade 3: 18.5%, grade 4: 26.9%).

--Contractile ERM was present in 44.1% of patients with EVG as compared to 18.6% in a random age- and gender-matched control cohort without EVG.

Finally, en face OCT will identify epivascular glia that have previously been identified using histopathology and scanning electron microscopy. These lesions were linked to advanced PVD, pseudophakia, and older age, implying a role for Muller cell activation through ILM breaks triggered by PVD.

Source: https://www.sciencedirect.com/science/article/abs/pii/S0002939421001276?dgcid=rss_sd_all
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