Encephalopathy, other neurologic manifestations occur freque
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Covid-19 can involve multiple organs including the nervous system. Researchers sought to characterize the neurologic manifestations, their risk factors, and associated outcomes in hospitalized patients with Covid-19.

Researchers examined neurologic manifestations in 509 consecutive patients admitted with confirmed Covid-19 within a hospital network in Chicago, Illinois. They compared the severity of Covid-19 and outcomes in patients with and without neurologic manifestations. They also identified independent predictors of any neurologic manifestations, encephalopathy, and functional outcome using binary logistic regression.

-- Neurologic manifestations were present at Covid-19 onset in 215 (42.2%), at hospitalization in 319 (62.7%), and at any time during the disease course in 419 patients (82.3%).

-- The most frequent neurologic manifestations were myalgias (44.8%), headaches (37.7%), encephalopathy (31.8%), dizziness (29.7%), dysgeusia (15.9%), and anosmia (11.4%).

-- Strokes, movement disorders, motor and sensory deficits, ataxia, and seizures were uncommon (0.2 to 1.4% of patients each).

-- Severe respiratory disease requiring mechanical ventilation occurred in 134 patients (26.3%).

-- Independent risk factors for developing any neurologic manifestation were severe Covid-19 and younger age.

-- Of all patients, 362 (71.1%) had a favorable functional outcome at discharge.

-- However, encephalopathy was independently associated with worse functional outcome and higher mortality within 30 days of hospitalization.

Neurologic manifestations occur in most hospitalized Covid-19 patients. Encephalopathy was associated with increased morbidity and mortality, independent of respiratory disease severity.

Source: https://onlinelibrary.wiley.com/doi/10.1002/acn3.51210
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