Endometrial Carcinoma Presenting as Vasculitic Sensorimotor
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Paraneoplastic neurologic disorders (PNDs) are remote effects of the cancer affecting any part of the central or peripheral nervous system, presenting with diverse symptoms. Common features of PNDs are usually rapid development, severity of the neurological illness, and appearance before the cancer diagnosis. According to the most widely recognized theory, the genesis is believed to be autoimmune mediated. An autoimmune response of the organism to antigens expressed by tumor cells is assumed. The antigens cause the body's immune system to produce antibodies in an attempt to suppress the cancer. These same antibodies can trigger an autoimmune attack on the brain and the neurological systems. The exact pathophysiological principles are not yet fully understood.
The incidence of paraneoplastic polyneuropathy (PNP) fluctuates between 10–40% among all patients with cancer, depending on diagnostic criteria. PNP is usually associated with small cell lung carcinoma, prostate, gastric, colon, or breast cancer, and lymphoma.
We report the particular case of a female patient with progressive vasculitic PNP associated with endometrial cancer presenting as severe asymmetrical sensorimotor deficit resembling a mononeuritis multiplex and proximal motor weakness.

Case Report
A 48-year-old, premenopausal Caucasian nulli gravida, was admitted to the Neurological Department of Aachen University Medical Center, complaining of weakness of upper and lower extremities and severe peripheral hypesthesia.....

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