Endometrial cancer driver mutations detectable in uterine la
Mutations that have been linked to endometrial cancer can be found in the uterine lavage fluid of pre- and post-menopausal women both with and without detectable cancer, according to a study published in PLOS Medicine by John Martignetti from the Icahn School of Medicine at Mount Sinai, New York, USA, and colleagues.

There are no effective screening methods for endometrial cancer, which is currently increasing in both incidence and mortality in the United States. In the new study, researchers performed uterine lavage - where the inside of the uterus is rinsed with saline fluid to collect loose cells and DNA - on 107 women undergoing diagnostic hysteroscopy due to post-menopausal uterine bleeding or abnormal pelvic ultrasound results. The cells and DNA collected were analyzed with either one of two next-generation sequencing panels to detect previously established driver mutations of endometrial cancer. Hysteroscopy samples were analyzed using classic histopathology....