Endophthalmitis after intravitreal anti-vascular endothelial
A Study was conducted to evaluate outcomes of eyes that developed endophthalmitis after intravitreal anti-vascular endothelial growth factor injections that were managed without microbiologic cultures.

Endophthalmitis cases were divided into the “culture group” if treated with intravitreal antibiotics and a vitreous or aqueous tap sent for microbiologic sampling.

--Of 165 endophthalmitis cases identified, 119 were in the “culture group” and 46 were in the “no culture group”.

--At endophthalmitis presentation, eyes in the “culture group” had a mean logMAR VA of 1.98 compared to 1.90 for eyes in the “no culture group”.

--At six-month follow-up, mean vision loss was 5.5 lines lost from baseline for the “culture group” compared to 2.5 lines lost for the “no culture” group.

--Eyes in the “culture group” required a subsequent pars plana vitrectomy in 29/119 cases compared to 7/46 cases in the “no culture group”.

--Six of 119 eyes in the “culture group” developed secondary retinal detachments compared to 0 in the “no culture group".

Conclusively, if a microbiologic facility is not accessible, intravitreal antibiotics without microbiologic cultures may be an acceptable therapeutic strategy for post-injection endophthalmitis.

Source: https://www.ajo.com/article/S0002-9394(21)00425-6/fulltext?rss=yes