Epigenetic Modification in MTHFR Gene and Pre-eclampsia in w
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According to a recent study by The Journal of Obstetrics and Gynecology of India, genetic and epigenetic factors play significant roles in the etiopathogenesis of pre-eclampsia (PE).

An observational, cross-sectional study was conducted, where 200 pregnant women diagnosed with pre-eclampsia(PE) (study group) and 200 pregnant normotensive and apparently healthy women (control group) were recruited for the study. The DNA Methylation status of the CpG island in the promoter region of the Methylene Tetrahydrofolate Reductase (MTHFR) gene was assessed using bisulfite conversion and methylation-specific PCR method.

The study found that;

--The homozygous MTHFR CpG island hypomethylation pattern was significantly associated with pre-eclampsia.

--The mean values of plasma homocysteine in PE women with homozygous hypomethylation were significantly higher than observed in PE subjects with homozygous hypermethylation.

--Red cell folate and Vitamin B12 levels were not significantly associated with CpG island methylation status.

The study concluded that epigenetic modification plays a significant role in the pathogenesis of pre-eclampsia.

Source: https://doi.org/10.1007/s13224-020-01374-w
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