Epilepsy drug stops nervous system tumor growth
People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. These tumors are usually benign -- meaning they don't spread to other parts of the body and are not considered life-threatening -- but they can still cause serious medical problems such as blindness, especially when they form in the brain and nerves.

Researchers have discovered that nerve cells with the mutation that causes NF1 are hyperexcitable and that suppressing this hyperactivity with the epilepsy drug lamotrigine stops tumor growth in mice. Hyperexcitable neurons are also a feature of epilepsy, and the epilepsy medication lamotrigine targets the same ion channel disrupted in hyperexcitable Nf1-mutant neurons. The researchers gave lamotrigine to a group of Nf1-mutant mice that develop optic nerve tumors. Compared to mice receiving placebo, mice that had received the drug had smaller tumors, which no longer were growing.

Source: https://www.sciencedaily.com/releases/2022/05/220519141028.htm
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