Erosive hand osteoarthritis is related to greater radiograph
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A Study was conducted to evaluate age, sex, race, osteoarthritis severity, metabolic factors, and bone health as risk factors for incident erosive hand osteoarthritis (EHOA) at baseline and over 48-month period.

This study was a longitudinal cohort design including participants from the Osteoarthritis Initiative with complete hand radiographs from baseline and 48-month visits who were eligible at baseline for incident EHOA. Individuals were classified as having EHOA if they had Kellgren-Lawrence (KL) grade more than 2 in at least one interphalangeal joint on two different fingers and central erosion in at least one joint.

--Of the 3365 individuals identified without prevalent EHOA at baseline, 86 developed EHOA during the 48-month period.
--Risk factors included being older [relative risk (RR) per standard deviati female RR=1.73 ], greater osteoarthritis severity (sum of KL grade 13.9 vs. 5.3 and less cortical width (1.38 vs 1.52 mm).

--After 48 months, people who developed EHOA were characterized by greater progressions of radiographic osteoarthritis (i.e., joint space narrowing, KL grade progression [RRs = 1.35 to 1.9] and loss of cortical thickness [RR = 1.23], adjusted for age, sex, race, body mass index, and baseline osteoarthritis severity (sum KL scores).

These results demonstrate EHOA as an old age and female sex disorder strongly linked to the degree and progression of joint structural deterioration. Persons with EHOA have thinner bones before development of EHOA and as it advances, EHOA is a skeletal fragility disorder.