Eruptions and Related Clinical Course Among 296 Hospitalized
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Limited information exists on mucocutaneous disease and its relation to course of COVID-19.

A Study was conducted to estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19. Prospective cohort study at two tertiary hospitals between May 11, 2020 and June 15, 2020 was done.

Results:
Among 296 hospitalized adults with COVID-19:
35 (11.8%) had at least one disease-related eruption. Patterns included ulcer (13/35), purpura (9/35), necrosis (5/35), non-specific erythema (4/35), morbilliform eruption (4/35), pernio-like lesions (4/35), and vesicles (1/35). Patterns also demonstrated anatomic site-specificity.

A greater proportion of patients with mucocutaneous findings used:- mechanical ventilation [61% vs. 30%], vasopressors [77% vs. 33%], initiated dialysis [31% vs. 9%], had thrombosis [17% vs. 11%], and had in-hospital mortality [34% vs. 12%] compared to those without mucocutaneous findings. Patients with mucocutaneous disease were more likely to use mechanical ventilation [adjusted PR 1.98].
Differences for other outcomes were attenuated after covariate adjustment and did not reach statistical significance.

Conclusively, distinct mucocutaneous patterns were identified in hospitalized adults with COVID-19. Mucocutaneous disease may be linked to more severe clinical course.

Source: https://www.jaad.org/article/S0190-9622(20)33242-4/fulltext?rss=yes
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