Estrogen may lessen severity of Covid-19 symptoms in women,
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In an effort to understand why men are at greater risk for more severe symptoms and worse outcomes from Covid-19 regardless of age, scientists at Wake Forest School of Medicine conducted a review of published preclinical data on sex-specific hormone activity, especially estrogen.

The review has been published in the September online issue of the journal Current Hypertension Reports.

Key Insights from the review:

• "We know that coronavirus affects the heart and we know that estrogen is protective against cardiovascular disease in women, so the most likely explanation seemed to be hormonal differences between the sexes," said the lead author.

• Groban's researchers said the published literature indicated that the angiotensin-converting enzyme2 (ACE2) is the cellular receptor of the coronavirus responsible for Covid-19 infections, and helps bring the virus into the cells of those organ systems.

• The review, they said, also pointed to estrogen's lowering the level of ACE2 in the heart, which may modulate the severity of Covid-19 in women.

• Conversely, higher levels of ACE2 in tissues could account for why symptoms are worse in men than women, Groban said.

Source: https://newsroom.wakehealth.edu/News-Releases/2020/08/Estrogen-May-Lessen-Severity-of-COVID19-Symptoms-in-Women
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