Evaluation of Inborn errors of metabolism and COVID-19: Stud
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Researchers aimed to evaluate the clinical findings of COVID-19 and describe the impact of SARS-CoV-2 infections on metabolic outcome in IEM patients. Infectious diseases can result a catabolic state and possibly trigger an acute metabolic decompensation in inborn errors of metabolism (IEM) that will even be life threatening.

Patients who were diagnosed as different types of IEM and developed microbiologically confirmed COVID-19 infection were included. Clinical findings and laboratory results were recorded retrospectively in terms of both IEM and COVID-19.

--11 patients with diagnosis of intoxication type metabolic disorders, 5 patients with energy metabolism disorders and 6 patients with complex molecular disorders were enrolled.

--The most frequent clinical finding was fever (52.1%) followed by fatigue/myalgia (47.8%). None of the patients was younger than 1 years of old. None of the patients presented severe or critical disease.

--In terms of metabolic decompensation, 2 patients diagnosed with propionic acidemia, 1 patient with methylmalonic acidemia and 1 patient with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency presented clinical and biochemical findings of an acute metabolic attack.

IEM, in particular, were not discovered to be a risk factor for severe COVID-19 infection. Patients with intoxication-type and energy metabolism abnormalities, on the other hand, should be regarded a sensitive population for COVID-19, as they are at a high risk of suffering acute metabolic decompensation, which can lead to life-threatening consequences.

Source: https://onlinelibrary.wiley.com/doi/10.1111/ped.14938?af=R