Evaluation of Outer nuclear layer overshadowed by Retinal ve
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A Study was conducted to investigate in vivo light-induced photoreceptor damage in retinitis pigmentosa (RP) using spectral-domain optical coherence tomography (SD-OCT) images.

Patients with EYS-related RP who had a genetic diagnosis were retrospectively tested. The thickness of the outer nuclear layer (ONL) under the retinal vessels was measured using SD-OCT vertical scans. As a control, the researchers used ONL thickness 100 microm superior and inferior to the vessel. The same tests were taken in healthy people.

The ONL preservation ratio was measured as the ratio of ONL thickness under vessel divided by the average of adjacent ONL thickness. SD-OCT vertical scans were used to determine the duration of the ellipsoid zone (EZ) from the fovea in patients with RP.

Results:
--30 EYS-associated RP patients and 25 healthy subjects were included.

--In both groups, ONL thickness overshadowed by retinal vessels was not significantly different from that of adjacent area.

--However, ONL preservation ratio of RP was larger than that of healthy control in both superior and inferior retina (1.03 vs 0.97, 1.15 vs 0.95, respectively).

--In RP, ONL preservation ratio was significantly larger in the inferior retina than superior retina.

--Furthermore, in RP patients, the EZ length from the fovea was always shorter in the inferior than superior retina and there was a significant difference.

In conclusion, patients with EYS-associated RP had inferior-dominant photoreceptor death and relative ONL preservation under retinal vessels. These findings indicate that photoreceptor death could be linked to long-term exposure to light in the atmosphere.

Source: https://www.nature.com/articles/s41433-021-01578-y?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+eye/rss/current+(Eye+-+Issue)
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