Evaluation of Retinal Nerve Fiber Layer, Ganglion Cell-Inner
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Myopic glaucoma suspects, particularly with high myopia, experience thinning of nontemporal parameters of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL), without change in optic nerve head (ONH) parameters.

The aim was to assess the effect of myopia on RNFL, GCIPL, and ONH parameters in glaucoma suspects.

76 eyes of glaucoma suspects studied with Cirrus high definition optical coherence tomography were divided into low (n=27), moderate (n=25), and high myopia (n=24) groups. Optical coherence tomography parameters were correlated with spherical equivalent (SE) and evaluated with areas under the receiver operating characteristic curve for quantifying diagnostic ability to differentiate high myopia from nonhigh myopia.

Results:
--In high myopia, SE was positively correlated with thinning of average, minimum, and nontemporal GCIPL and thinning of average and nontemporal RNFL but not for inferior RNFL.

--In moderate myopia, SE was correlated with thinning of inferonasal and minimum GCIPL as well as superior and inferior RNFL.

--SE was not correlated with ONH parameters in moderate or high myopia.

--The largest areas under the receiver operating characteristic curve for RNFL and GCIPL parameters were for superior (0.82) and superonasal (0.80) regions, respectively, with comparable diagnostic ability.

Finally, high myopia is related to thinning of the average RNFL, average and minimum GCIPL, and nontemporal parameters of both the RNFL and GCIPL, suggesting that refractive status should be considered in glaucoma suspects.

Source: https://journals.lww.com/glaucomajournal/Abstract/9000/Evaluation_of_Retinal_Nerve_Fiber_Layer,_Ganglion.97614.aspx
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