Evaluation of biomarkers and Safety in Systemic Sclerosis pa
A Study was conducted to evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc).

SSc patients with a rapidly progressive disease received paquinimod for 8 weeks. Blood and skin biopsies were collected at baseline, during treatment, and at follow-up for the analyses of type I interferon (IFN) activity, chemokine (C-C motif) ligand 2 (CCL2), and the number of myofibroblasts. The safety of paquinimod was evaluated throughout the study.

Results:
--9 SSc patients were enrolled and completed the study treatment with paquinimod at 3 mg/day for 8 weeks.

--After the treatment, a reduction of type I IFN activity in the plasma from one patient with elevated baseline IFN activity was recorded.

--A trend towards reduced IFN activity in the skin after treatment was also observed in patients.

--The serum level of CCL2 was reduced in 7 of 9 patients after paquinimod treatment.

--There was a median reduction of 10% of the number of myofibroblasts in skin biopsies at week 8 compared to baseline.

--No change in modified Rodnan skin score and quality of life was detected in the study. Reported adverse events (AEs) were mild to moderate and expected with the most common being arthralgia (n = 3) and headache (n = 3), and C-reactive protein (CRP) increase.

Biomarker study before and after therapy reveals decreased type I IFN activity and a lower number of myofibroblasts in the lesional skin. Paquinimod was well tolerated generally, with mild to moderate AEs that were predicted.

Source: https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-021-02573-0
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