Evaluation of the genotoxic effects of orthodontic NiTi wire
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Orthodontic wires are one of the main components of fixed appliance treatment. Bio-degradation of the metals in these wires could be a source of genotoxicity in the oral cavity. NiTi wires are considered more genotoxic compared to SS wire.

After the ethical committee's approval and obtaining patient consent, the oral buccal mucosal smears were collected from buccal mucosa using a metal spatula from 27 patients before bonding, during NiTi, and during the SS wire stage. The MN assay test was performed using the Papanicolaou staining procedure. The micronuclei were examined and counted using previously reported criteria under an electron microscope before bonding, during NiTi, and during the SS wire stage.

It determined that mean mucosa cells differed statistically significantly between time points. Post hoc tests using the Bonferroni correction showed that there was an increase in MN cells from before bonding brackets to the tooth to during the NiTi wire stage, and a reduced count from NiTi wire stage to SS wire stage.

In particular, the orthodontic wires were observed to be genotoxic. The NiTi wire is considered to have more potential to cause genotoxicity when compared to SS wires. This could be because of the Ni element present in a higher percentage in NiTi wire as compared to SS wire, hence, element Ni can be considered to be genotoxic.

Journal of Orofacial Sciences
Source: https://www.jofs.in/text.asp?2020/12/2/91/309583
Like
Comment
Share