Exercise Training to Increase Tumor NK Cell Infiltration in
Thirty patients with localized PCa undergoing radical prostatectomy were randomized (2:1) to either preoperative aerobic high-intensity interval training (HIIT) four times weekly or usual care from time of inclusion until scheduled surgery. The change in tumor NK cell infiltration did not differ between the EX and CON group in the intention-to-treat analysis. The total number of exercise sessions varied considerably from 4 to 30 sessions. The per-protocol analysis showed a significant increase in tumor NK cell infiltration of 1.60 cells/mm2 in the EX group. Further, the total number of training sessions was positively correlated with the change in NK cell infiltration and peak power output. Conclusively, Preoperative HIIT did not result in between-group differences in tumor NK cell infiltration. Per-protocol and exploratory analyses demonstrate an enhanced NK cell infiltration in PCa. Future studies are needed to test the capability of exercise to increase tumor immune cell infiltration.

Source: https://bjui-journals.onlinelibrary.wiley.com/doi/10.1111/bju.15842?af=R