Exercise capacity reduced in young adults born small for ges
A cohort of young adults born small for gestational age demonstrated marked reductions in exercise capacity compared with a control group in a new study.

Being born small for gestational age (SGA), approximately 10% of all births, is associated with increased risk of cardiovascular mortality in adulthood, but mechanistic pathways are unclear. Cardiac remodeling and dysfunction occur in fetuses SGA and children born SGA, but it is uncertain whether and how these changes persist into adulthood.

This study aimed to evaluate baseline cardiac function and structure and exercise capacity in young adults born SGA.

This cohort study assessed a perinatal cohort born at a tertiary university hospital in Spain. Participants included 158 randomly selected young adults aged 20 to 40 years born SGA (birth weight below the 10th centile) or with intrauterine growth within standard reference ranges (controls). Participants provided their medical history, filled out questionnaires regarding smoking and physical activity habits, and underwent incremental cardiopulmonary exercise stress testing, cardiac magnetic resonance imaging, and a physical examination, with blood pressure, glucose level, and lipid profile data collected.

Cardiac structure and function assessed by cardiac magnetic resonance imaging, including biventricular end-diastolic shape analysis. Exercise capacity assessed by incremental exercise stress testing.

-- This cohort study included 81 adults born SGA (median age at study, 34.4 years; 43 women [53%]) and 77 control participants (median age at study, 33.7 years; 33 women).

-- All participants were of White race/ethnicity and underwent imaging, whereas 127 participants (80% of the cohort; 66 control participants and 61 adults born SGA) completed the exercise test.

-- Cardiac shape analysis showed minor changes at rest in right ventricular geometry with preserved cardiac function in individuals born SGA.

-- However, compared with controls, adults born SGA had lower exercise capacity, with decreased maximal workload and oxygen consumption.

-- Exercise capacity was significantly correlated with left ventricular mass.

Conclusively, this cohort of young adults born SGA had markedly reduced exercise capacity. These results support further research to clarify the causes of impaired exercise capacity and the potential association with increased cardiovascular mortality among adults born SGA.

Source: https://jamanetwork.com/journals/jamacardiology/article-abstract/2781975