Exploring how genetics affects the functions of the gut micr
The trillions of individual organisms constituting a person's gut microbiome greatly impact metabolic function, disease and overall health. What has been less clear is how and to what extent the gut microbiome is, in turn, shaped by the genome of its human host.

The novelty of the current study was to make use of this structure in the data. It focused on the function of the gut microbiome as opposed to the genetic makeup of each species in the agglomeration of organisms that forms the microbiome; it looked at broad collections of human genes and their effect on the functions of the microbiome as opposed to examining single genes; and it used a new type of strategy to model the distribution of functions and species within the human gut.

When a disease or phenotype is caused by a single genetic mutation it can be a relatively straightforward process to find the gene responsible. an entire suite of genes can interact to result in disease or other phenotypic expression, a much more complex mechanism. Within the human genome there are many sequential variations from person to person and even within paired chromosomes of the same person. Associating variation in the human genome with the variation in the gut microbiome has been tricky, because the human genome variants are correlated with each other, and can have related functions, and the species of bacteria in the gut are also not independent of each other.

Source: https://medicalxpress.com/news/2022-04-exploring-genetics-affects-functions-gut.html