Extramammary Paget’s Disease of Anal Canal Associated With R
A 68-year-old gentleman with past history of renal cell carcinoma, prostatic adenocarcinoma and metastatic thyroid cancer but with no history of colorectal carcinoma underwent hemorrhoidectomy for recurrent internal hemorrhoids. On histological examination of the hemorrhoidectomy specimen in addition to a hemorrhoidal lesion, large atypical cells with pale and vacuolated cytoplasm were noted infiltrating the squamous epithelium of the anal mucosa. The atypical cells were positive for mucicarmine, CK20, CEA and CK7 (focally) and negative for melan A and GCDFP15 (Fig. 1). CDX2 immunohistochemistry was not performed. A diagnosis of anal EMPD was rendered. In addition to this, a detached portion of colonic mucosa involved by adenoma was noted. There was no evidence of invasive malignancy in the specimen....