Extreme uric acid in blood can reduce lifespan by 11 years,
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Elevation of serum uric acid (SUA) is associated with increased mortality; however, controversy exists regarding the nature of the relationship and differences between men and women. Researchers explored relationships of SUA levels with all-cause mortality in a large cohort of patients within the Irish health system.

A retrospective cohort study of 26,525 participants was conducted using data from the National Kidney Disease Surveillance System. SUA was modelled in increments of 59.48 µmol/L (1 mg/dL), Cox's proportional hazards model estimated hazard ratios (HRs) and 95% Confidence Intervals (CI), median lifetimes were also computed separately for men and women.

-- There were 1,288 (4.9%) deaths over a median follow-up of 5.1 years. In men, the risk of mortality was greatest for the lowest (less than 238 µmol/L) and highest (more than 535 µmol/L) categories; the corresponding median lifetimes for men were reduced by 9.5 and 11.7 years respectively compared to the referent.

-- In women, mortality risks were elevated for SUA greater than 416 mol/L [HR 1.69 (1.13–2.47) and beyond; the corresponding median lifetime for women were reduced by 5.9 years compared to the referent.

-- Spline analysis revealed a U-shaped association between SUA and mortality in men, while for women, the pattern of association was J-shaped.

Conclusively, mortality patterns attributed to SUA differ between men and women. Optimal survival was associated with SUA concentrations of 304–454 µmol/L for men and < 409 µmol/L for women.

Source: https://www.ejinme.com/article/S0953-6205(20)30378-2/fulltext