Exuberant oral lesions in an immunocompromised patient: Case
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A 32-year-old male, reported with lesions in the oral mucosa with one year of evolution. The patient maintained a low TCD4+ lymphocyte count due to Human Immunodeficiency Virus (HIV). On physical examination, multiple rose-pink to white papules and plaques with a soft consistency were found on lower and upper lips and gums.

Histopathology of the skin by routine staining showed parakeratosis, acanthosis with robust rete ridges and koilocytes. In the lamina propria there is a chronic subepithelial inflammatory infiltrate and dilated capillaries. A molecular testing for high-risk oncogenic DNA-HPV was positive. Based on patient's history, physical examination and histopathological findings, Condyloma accuminatum in the oral cavity is diagnosed. It is a rare disease, & is sexually transmitted. HPV 6 and 11 are associated with a low oncogenic risk, while HPV 16 and 18 are related to a high oncogenic risk. These four HPV subtypes are commonly detected in oral CA. The molecular analysis was positive for high-risk oncogenic DNA-HPV in the presented case.

Considering the oncogenic nature of HPV, patients should be instructed on the use of preventive methods and HPV vaccine
schedule.

Source: https://www.jaadcasereports.org/article/S2352-5126(20)30835-3/fulltext?rss=yes
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