FDA Approves Gleolan
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The U.S. Food and Drug Administration (FDA) has approved Gleolan [aminolevulinic acid hydrochloride (ALA HCl)] as an optical imaging agent indicated in patients with gliomas (suspected World Health Organization Grades III or IV on preoperative imaging) as an adjunct for the visualization of malignant tissue during surgery. The approved recommended reconstituted oral dose of Gleolan is 20 mg/kg administered 3 hours (range 2 to 4 hours) prior to induction of anesthesia. During neurosurgery, Gleolan is used with an operating microscope adapted with a blue emitting light source and filters for excitation light of wavelength 375 to 440 nm, and observation at wavelengths of 620 to 710 nm...

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