Factors associated with Real-Life Functioning in Persons wit
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Findings of this study suggest that several variables associated with real-life functioning at follow-up are not routinely assessed and targeted by intervention programs and that personalized interventions aimed at promoting cognition and independent living should be an integral part of management programs for schizophrenia.

The goal of schizophrenia treatment has shifted from symptom reduction and relapse prevention to functional recovery; however, recovery rates remain low. The objective of the study was to assess whether baseline illness-related variables, personal resources, and context-related factors are associated with work skills, interpersonal relationships, and everyday life skills.

This multicenter prospective cohort study was conducted with 921 patients who were contacted after 4 years for reassessment. Recruitment of community-dwelling, clinically stable persons with schizophrenia were conducted and data were analyzed.

In total, 618 participants were included. In the latent change score model, higher neurocognitive abilities were associated with improvement of everyday life and work skills, social cognition, and functional capacity; better baseline social cognition with an improvement of work skills and interpersonal functioning; and better baseline everyday life skills with an improvement of work skills.

Conclusively, the key roles of social and nonsocial cognition and of baseline everyday life skills support the adoption in routine mental health care of cognitive training programs combined with personalized psychosocial interventions aimed to promote independent living.

JAMA Psychiatry
Source: https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2776050