Factors predictive of cystoid macular oedema following endot
A Study was conducted to describe the incidence of postoperative cystoid macular oedema (CMO) after endothelial keratoplasty (EK) and to identify its contributory risk factors.

2233 patients undergoing EK at Ospedali Privati Forlì ‘Villa Igea’, for Descemet stripping automated endothelial keratoplasty (DSAEK) and for Descemet membrane endothelial keratoplasty (DMEK) with a minimum follow-up of 18 months were evaluated. Univariate and multivariate analyses were conducted to identify and quantify contributory risk factors. Receiver operating characteristic (ROC) curve analysis were performed to determine ideal cut-off points of continuous variables.

Results:
--CMO was identified in 2.82% (n=63) of the cases. CMO occurred in 2.36% of DSAEK eyes and in 5.56% of DMEK eyes.

--Average onset of CMO was 4.27±6.63 months (range: 1–34 months) postoperatively.

--Compared with those who did not develop CMO, a higher proportion of patients in the CMO group had diabetes (24.2% vs 9.8%) (OR=3.16), a higher proportion of patients who underwent DMEK rather than DSAEK (28.6% vs 14.1%) (OR=2.42) and were older.

--Using the cut-off of 67 years as identified by ROC curve analysis, subjects aged more than 67 years were more likely to develop CMO.

Finally, older age, DMEK and diabetes mellitus were discovered for post-operative CMOs following EK as independent risk variables. In particular, in patients with risk factors, close supervision is recommended throughout the first post-operative year after EK.

Source: https://bjo.bmj.com/content/early/2021/07/22/bjophthalmol-2020-318076?rss=1
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