Factors that affect Exhaled breath condensate pH in school-a
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The pH of exhaled breath condensate (EBC) is a promising airway inflammation biomarker. Researchers wanted to see if there was a connection between asthma and EBC pH in children, as well as look into possible environmental factors that could cause interstudy variability.

Exhaled breath condensates from 613 children aged 7 to 12 years were analyzed cross-sectionally. Lung function and airway reversibility, exhaled nitric oxide, allergic sensitization, and body mass index were all evaluated (BMI). During five school days, the indoor air quality (IAQ) of children's classrooms was measured. The pH of EBC after deaeration had a bimodal distribution, so the sample was divided into acidic and alkaline groups. To assess the effects of asthma and asthma adjusted to IAQ parameters on EBC pH, regression models were developed.

Results:
--Following adjustment to gender and BMI, asthma was significantly associated with a lower EBC pH in the acidic group.

--The effect of asthma on EBC pH was independent of IAQ, in both groups. In the acidic group, EBC pH was significantly affected by temperature [beta = -0.09] and PM2.5 concentration [beta = -0.16], and in the alkaline group by relative humidity [beta = 0.07] and concentration of endotoxins [beta= -0.06].

In conclusion, the study indicates that, in addition to individual determinants such as asthma, environmental factors may affect EBC pH levels in children and should be taken into account when interpreting them.

Source: https://onlinelibrary.wiley.com/doi/10.1111/pai.13564?af=R
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