Family history of type 2 diabetes and characteristics of chi
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Shared etiopathogenetic factors have been proposed in type 1 diabetes and type 2 diabetes and both diseases have been shown to cluster in families. Characteristics related to type 2 diabetes have been described in patients with type 1 diabetes with a positive family history of type 2 diabetes. Researchers wanted to characterize the family history of type 2 diabetes and its possible effects on the phenotype and genotype of type 1 diabetes in affected children at diagnosis.

A total of 4993 children under the age of 15 years with newly diagnosed type 1 diabetes from the Finnish Pediatric Diabetes Register were recruited (56.6% boys, median age of 8.2 years) for a cross-sectional, observational, population-based investigation. The family history of diabetes at diagnosis was determined by a structured questionnaire, and markers of metabolic derangement, autoantibodies and HLA class II genetics at diagnosis were analyzed.

Results:
-- Two per cent of the children had an immediate family member and 36% had grandparents with type 2 diabetes.

-- Fathers and grandfathers were affected by type 2 diabetes more often than mothers and grandmothers.

-- The children with a positive family history for type 2 diabetes were older at the diagnosis of type 1 diabetes, had higher BMI-for-age and more often tested negative for all diabetes-related autoantibodies.

Conclusively, features associated with type 2 diabetes, such as higher body weight, older age at diagnosis and autoantibody negativity, are more frequently already present at the diagnosis of type 1 diabetes in children with a positive family history of type 2 diabetes.

Source: https://link.springer.com/article/10.1007/s00125-020-05342-x
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