Fat buildup in liver linked to heightened heart failure risk
A meta-analysis of observational studies to quantify the magnitude of the association between NAFLD and risk of new-onset HF. Researchers identified 11 longitudinal cohort studies with aggregate data on 11242231 middle-aged individuals from different countries and 97716 cases of incident HF over a median of 10 years. NAFLD was associated with a moderately higher risk of new-onset HF (pooled random-effects hazard ratio 1.50, 95% CI 1.34 to 1.67, p<0.0001; I2=94.8%). This risk was independent of age, sex, ethnicity, adiposity measures, diabetes, hypertension, and other common cardiovascular risk factors. NAFLD is associated with a 1.5-fold higher long-term risk of new-onset HF, regardless of the presence of diabetes, hypertension, and other common cardiovascular risk factors.

Source: https://gut.bmj.com/content/early/2022/06/22/gutjnl-2022-327672
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