Fatigue among children with a chronic disease
To determine: (1) which biological/lifestyle, psychological, and/or social factors are associated with fatigue among children with a chronic disease and (2) how much each of these factors contribute to explaining variance in fatigue a study was conducted.

Researchers included children aged 8–18 years who visited the outpatient clinic with cystic fibrosis, an autoimmune disease, or postcancer treatment. A total of 434 out of 902 children were included (48% participation rate), with a median age of 14.5 years; 42% were male. Among these 434 children, 21.8% were severely fatigued. Together, all biopsychosocial factors explained 74.6% of the variance in fatigue. More fatigue was uniquely associated with poorer physical functioning, more depressive symptoms, more pressure at school, poorer social functioning, and older age.

Fatigue among children with a chronic disease is multidimensional. Multiple generic biological/lifestyle, psychological and social factors were strongly associated with fatigue, explaining 58.4%; 65.8%, and 50.0% of the variance in fatigue, respectively. Altogether, almost three-quarters of the variance in fatigue was explained by this biopsychosocial model. Thus, when assessing and treating fatigue, a transdiagnostic approach is preferred, taking into account biological, psychological, and social factors.

What does this study add?

-Fatigue is a multidimensional concept spanning pediatric chronic diseases, with strong, overlapping correlations with biological, psychological, and social factors.

-Therefore, these factors should be taken into account when assessing and treating fatigue in this patient population.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893660/