First Data on COVID Vaccines in Pregnancy
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
COVID-19 vaccines appeared safe in pregnant women, with side effects that were consistent with those in non-pregnant people, researchers found.

Many pregnant persons in the United States are receiving messenger RNA (mRNA) coronavirus disease 2019 (Covid-19) vaccines, but data are limited on their safety in pregnancy.

From December 14, 2020, to February 28, 2021, researchers used data from the “v-safe after vaccination health checker” surveillance system, the v-safe pregnancy registry, and the Vaccine Adverse Event Reporting System (VAERS) to characterize the initial safety of mRNA Covid-19 vaccines in pregnant persons.

A total of 35,691 v-safe participants 16 to 54 years of age identified as pregnant.

--Injection-site pain was reported more frequently among pregnant persons than among nonpregnant women, whereas headache, myalgia, chills, and fever were reported less frequently.

--Among 3958 participants enrolled in the v-safe pregnancy registry, 827 had a completed pregnancy, of which 115 resulted in a pregnancy loss and 712 resulted in a live birth.

--Adverse neonatal outcomes included preterm birth and small size for gestational age; no neonatal deaths were reported.

--Although not directly comparable, calculated proportions of adverse pregnancy and neonatal outcomes in persons vaccinated against Covid-19 who had a completed pregnancy were similar to incidences reported in studies involving pregnant women that were conducted before the Covid-19 pandemic.

--Among 221 pregnancy-related adverse events reported to the VAERS, the most frequently reported event was spontaneous abortion.

Conclusively, preliminary findings did not show obvious safety signals among pregnant persons who received mRNA Covid-19 vaccines.

The New England Journal of Medicine
Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2104983
1 share
Like
Comment
Share