First Evidence of SARS-CoV-2 in Heart Cells- The Lancet
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SARS-CoV-2 has been found in cardiac tissue of an 11-year-old child from Brazil with multisystem inflammatory syndrome (MIS-C) related to COVID-19 who presented with myocarditis and died of heart failure.

It's believed to be the first evidence of direct infection of heart muscle cells by the virus; viral particles were identified in different cell lineages of the heart, including cardiomyocytes, endothelial cells, mesenchymal cells, and inflammatory cells.

Patient was admitted to the paediatric ICU with cardiovascular shock and persistent fever. Her initial symptoms were fever for 7 days, odynophagia, myalgia, and abdominal pain. On admission to the ICU, the patient presented with respiratory distress, comprising tachypnoea and hypoxia, and signs of congestive heart failure, including jugular vein distention, crackles at the base of the lungs, displaced liver, hypotension, tachycardia, and cold extremities with filiform pulses.

A point-of-care ECG showed diffuse left-ventricular hypokinesia with no segmental wall motion abnormalities. Initial radiography showed an enlarged cardiac area and bilateral lung opacities. Chest CT showed multiple ground-glass pulmonary opacities.

Analysis of cardiac tissue by electron microscopy identified spherical viral particles of 70–100 nm in diameter, consistent in size and shape with the Coronaviridae family. SARS-CoV-2-associated pneumonia was mild, with patchy exudative changes in alveolar spaces and mild pneumocyte hyperplasia. SARS-CoV-2 RNA was detected on a post-mortem nasopharyngeal swab and in cardiac and pulmonary tissues by real time RT-PCR using primers and probes set for E (envelope) gene.

Moreover, the finding of SARS-CoV-2 in heart tissue indicates that myocardial inflammation was probably a primary response to the virus-induced injury to cardiac cells. The presence of SARS-CoV-2 in different cell types of cardiac tissue suggests potential mechanisms for heart damage.

Dr. S●●●●●●●●●●n K●●●●●●i and 4 others like this7 shares
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A●u A●●●r L●●●●r General Medicine
Very informative
Aug 25, 2020Like