Floppy Infant with Respiratory Failure: A Case of Infantile
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Inflammatory myopathies are heterogenous group of skeletal muscle diseases with onset ranging from infancy to adulthood. Three distinct groups: dermatomyositis, polymyositis and sporadic inclusion body myositis are defined. Polymyositis affects predominantly adults but rarely children and infants. A few case reports on infantile polymyositis [3-5], clinically presenting with moderate to severe muscle weakness, generalised hypotonia, with elevated serum creatine kinase (CK) activity, myopathic electromyography changes and inflammatory cell infiltrates on muscle biopsy have been reported. In this report we describe a floppy child with respiratory failure, elevated CK and muscle biopsy showing features of polymyositis.An eleven month old infant presented with progressive proximal muscle weakness, hypotonia and elevated creatinekinase. Muscle biopsy showed inflammatory changes suggestive of polymyositis. Infantile polymyositis, an inflammatory myopathy affecting children under 1 year of age is a rare disorder but potentially treatable. Early diagnosis is crucial for better outcome...

https://www.omicsonline.org/open-access/floppy-infant-with-respiratory-failure-a-case-of-infantile-polymyositis-2161-0665-1000316.php?aid=86802
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