Fluoroquinolones raise aortic aneurysm, dissection risks: St
Exposure to fluoroquinolones was highly associated with risk for aortic aneurysm and aortic dissection, researchers reported in recently published studies in the Journal of the American College of Cardiology.

The researchers conducted a case-crossover analysis of a Taiwanese national administrative database, focusing on 1,213 patients hospitalized for aortic aneurysm or aortic dissection between 2001 and 2011 and 1,213 matched controls.

For each patient, the researchers compared fluoroquinolone exposure during a 60-day period before aortic aneurysm or aortic dissection diagnosis (hazard period) with exposure during a randomly selected 60-day period within 60 to 180 days before hospitalization (referent period). They performed subsequent analyses to adjust for time-variant confounders and time-trend biases.

In the main analysis, exposure to fluoroquinolones was more frequent during the hazard period than during the referent period. In a sensitivity analysis adjusted for infections and co-medications, the risk did not change.

A longer exposure to fluoroquinolones conferred a greater risk for aortic aneurysm and aortic dissection. In a susceptible period analysis, the researchers found exposure to fluoroquinolones within 60 days of aortic aneurysm or aortic dissection diagnosis was associated with high risk for aortic aneurysm or aortic dissection but exposure within 120 or 180 days was not.

In a case-time-control analysis, temporal changes in fluoroquinolone exposure were not related to aortic aneurysm or aortic dissection risk.

Read more here: https://pxmd.co/3uq7O
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