Folic acid-conjugated amphiphilic alternating copolymer as a
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Conventional chemotherapy is one of the most common treatments for cancer; however, current technologies suffer from limitations such as poor aqueous solubility, which causes elevated toxicity, lack of selectivity toward cancer cells, and multiple drug resistance against treatments.The application of nanotechnology to deliver drugs to tumor cells is an attractive alternative. It allows drug to be delivered to cancer cells specifically with prolonged circulation time and with a controlled drug release.In addition, controlled drug delivery improves bioavailability by preventing premature degradation and enhancing uptake, as well as by maintaining drug concentration and release rate within the therapeutic window, while reducing side effects by targeting cancer cells.The present study describes a strategy to develop a “smart” drug carrier with all three delivery strategies....

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170841/
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