For Pediatric Community-Acquired Pneumonia Short-Course Anti
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Community-acquired pneumonia (CAP) is a common occurrence in childhood. A Study was conducted to determine whether 5 days of high-dose amoxicillin for CAP was associated with noninferior rates of clinical cure compared with 10 days of high-dose amoxicillin.

The SAFER (Short-Course Antimicrobial Therapy for Pediatric Respiratory Infections) study was a 2-center, parallel-group, noninferiority randomized clinical trial consisting of a single-center pilot study. Research staff, participants, and outcome assessors were blinded to treatment allocation. Eligible children were aged 6 months to 10 years and had fever within 48 hours, respiratory symptoms, chest radiography findings consistent with pneumonia as per the emergency department physician, and a primary diagnosis of pneumonia.

5 days of high-dose amoxicillin therapy followed by 5 days of placebo (intervention group) vs 5 days of high-dose amoxicillin followed by a different formulation of 5 days of high-dose amoxicillin (control group).

--Among the 281 participants, the median age was 2.6 years.
--Clinical cure was observed in 101 of 114 children in the intervention group and in 99 of 109 in the control group in per-protocol analysis.
--Clinical cure at 14 to 21 days was observed in 108 of 126 in the intervention group and in 106 of 126 in the control group in the intention-to-treat analysis (risk difference, 0.023).

Finally, for the treatment of previously stable children with CAP who did not need hospitalization, short-course antibiotic therapy proved to be equivalent to standard care. In compliance with antimicrobial stewardship standards, clinical practice recommendations should suggest prescribing 5 days of amoxicillin for pediatric pneumonia control.
Source: https://jamanetwork.com/journals/jamapediatrics/fullarticle/2776976?guestAccessKey=9c7ce08e-36dd-49d5-9cf3-aa08dd770a30&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jamapediatrics&utm;_c
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