For Venous Thromboembolism Prophylaxis, 30 Days of Aspirin i
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To prevent venous thromboembolism (VTE) after total knee arthroplasty (TKA), 30 days of aspirin prophylaxis is recommended. The aim of this study was to see when VTE happened after TKA in patients who took low and high doses of aspirin, and whether 30-days of prophylaxis was enough.

Researchers looked at the reports of 9,208 patients who had primary TKA and were given low (81 mg twice daily, n=4,413) or heavy (325 mg twice daily, n=4,795) dose aspirin for VTE prevention. Symptomatic VTE that occurred within 90 days of surgery was also discovered. Within the first 30-days, there were also major bleeding incidents (MBE). The time it took for the event to occur was registered.

Results:
--Overall, 88 patients developed symptomatic VTE, with no significant differences in incidence between the low (n=40, 0.9%) and high (n=48, 1.0%) dose groups.

--The median time to VTE was 8 days, median time to DVT was 12 days and median time to PE was 5 days.

--There was a similar distribution in time to VTE in both the low and high dose groups.

--Aside from a single DVT occurring at day 44, all VTE occurred within 30 days of surgery.

--During the prophylactic time period, 41 patients (0.4%) developed MBE, which tended to occur more frequently (0.6% vs 0.3%) and earlier in the high dose group.

Finally, the results show that a 30-day low or high-dose aspirin regimen is still the best way to avoid VTE in TKA patients without of MBE.

Source: https://www.sciencedirect.com/science/article/abs/pii/S0883540321004162?dgcid=rss_sd_all
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