For diabetic macular edema, panretinal photocoagulation afte
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Panretinal photocoagulation treatment (PRP) have been known as a standard treatment for proliferative diabetic retinopathy (PDR) or severe nonproliferative diabetic retinopathy (sNPDR). This study is to evaluate the difference between two groups of PRP prior to, or after intravitreal conbercept (IVC) for patients with PDR or sNPDR combined with diabetic macular edema (DME).

This was a retrospective study in which 58 eyes with DME secondary to PDR or sNPDR were divided into two groups;
--The PRP after (PRP-after group), or prior to (PRP-prior group),
--The PRP after IVC.
Changes in number of IVC injections, best corrected visual acuity (BCVA), and central subfield macular thickness (CSMT) were compared after 4?weeks, 12?weeks, 1?year, and 2?years from the first IVC injection.

Results:
--The mean number of injections in PRP-after group was 4.8 and 6.4, lower than 6.4 (1?year) and 8.5 (2?year) in PRP-prior group.

--There was no significant difference in change in BCVA and CSMT between two groups after each follow-up.

Finally, PRP after IVC needs fewer injections but shows comparable visual and anatomic outcomes in patients with diabetic retinopathy and DME as compared to PRP before IVC.

Source: https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-021-01920-8
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